Thermo Fisher Scientific IRAK2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody reacts with all four isoforms of IRAK2a.
A suggested positive control is A-20 cell lysate.
PA5-20164 can be used with blocking peptide PEP-0281.

Target Information

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular responses through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, a pivotal transcription factor mediating inflammatory and immune responses.
A novel member in the IRAK/Pelle family, IRAK2, recruits to the subunits of the IL-1R complex after IL-1 binding and leads to NF-kappa-B activation.
IRAKs also associate with Toll-like receptor (TLR), and dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation.
Members in the IRAK/Pelle family play a central role in IL-1R and TLR-mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.