Thermo Fisher Scientific PDGFRB Polyclonal Antibody
PDGFRB 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관을 권장합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human PDGF Receptor beta. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.63 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792954 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Bovine (83%).
- Positive Control: SK-N-SH, SK-N-AS.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The receptor can form homodimers or heterodimers with PDGF receptor alpha, depending on the bound ligand. The PDGFRB gene is located on chromosome 5 near genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, potentially involved in the 5-q syndrome.
A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with the ETV6 leukemia gene results in a chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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