Thermo Fisher Scientific AVEN Polyclonal Antibody

Thermo Fisher Scientific AVEN Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: 293T, A431, HeLa, HepG2.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer.
Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation.
Higher levels of Aven mRNA are observed in patients with acute leukemia compared to control patients, suggesting that Aven may serve as a prognostic indicator in leukemia.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

Usage Restrictions

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.