Thermo Fisher Scientific AVEN Polyclonal Antibody
Human AVEN 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포사멸 연구 및 백혈병 관련 연구에 활용 가능. PBS 기반 용액 형태로 장기 보관 시 -20°C 저장 권장.
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Thermo Fisher Scientific AVEN Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human AVEN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792575 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: 293T, A431, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer.
Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation.
Higher levels of Aven mRNA are observed in patients with acute leukemia compared to control patients, suggesting that Aven may serve as a prognostic indicator in leukemia.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Restrictions
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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