Thermo Fisher Scientific Multi-Drug Resistance Marker (P-Glycoprotein) Monoclonal Antibody (ABM137)
P-Glycoprotein 표적 단백질에 대한 단일클론 항체로 인간 시료에 반응. IHC(Paraffin) 적용 가능하며, 단백질 A로 정제된 액상 형태. 약물 내성 연구 및 ATP-binding cassette 수송체 분석에 적합. 4°C 단기, -20°C 장기 보관 권장.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM137 |
| Immunogen | Recombinant protein containing four tandem repeats of amino acid sequences near the C-terminus of P-Glycoprotein (ABCB1, UniProt ID: P08183-1, NCBI Node ID: 9606, Antigen Range: 1280, Antigen Length: 1280) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Positive control: Adrenal gland tissue
- Cellular location: Membrane, Cytoplasmic
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, responsible for decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs.
Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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