Thermo Fisher Scientific Axl Polyclonal Antibody
Rabbit polyclonal antibody against human AXL protein. Validated for WB and IHC applications. High specificity with predicted reactivity across multiple species. Supplied as liquid form, purified by antigen affinity chromatography, and suitable for rese...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 469–848 of Human AXL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546326 |
Product Specific Information
- Recommended positive controls: A549, H1299, human AXL-transfected 293T
- Predicted reactivity: Human (99%), Mouse (97%), Rat (97%), Pig (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. It encodes a receptor tyrosine kinase that transduces extracellular matrix signals into the cytoplasm by binding growth factors such as vitamin K-dependent protein GAS6, promoting cell proliferation.
TAM receptors, including AXL, are involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors exhibit degenerative phenotypes and autoimmune characteristics similar to systemic lupus erythematosus.
AXL may act as an entry receptor for filoviruses and serves as a marker for specific dendritic cell subpopulations (Siglec 6+/Axl+). Its expression can be upregulated by TLR ligands (e.g., LPS, poly I:C). Soluble AXL is generated by proteolytic cleavage, and elevated plasma levels can indicate inflammation or cancer.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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