Thermo Fisher Scientific RNaseL Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RNASEL. Recombinant protein control fragment (Product #RP-102053). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RNaseL,uniProtId:Q05823-1,ncbiNodeId:9606,antigenRange:323-468,antigenLength:741,antigenImageFileName:PA5-82024_RNaseL_Q05823-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82024_RNaseL_Q05823-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789185

Product Specific Information

Immunogen sequence: HGAKEDFHPP AEDWKPQSSH WGAALKDLHR IYRPMIGKLK FFIDEKYKIA DTSEGGIYLG FYEKQEVAVK TFCEGSPRAQ REVSCLQSSR ENSHLVTFYG SESHRGHLFV CVTLCEQTLE ACLDVHRGED VENEEDEFAR NVLSSI

Target Information

A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.