Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Western blot에 적합한 Caspase-12 폴리클로날 항체로, 염소 유래 IgG 포맷. ER 스트레스 관련 세포사멸 연구에 활용 가능. 액상 형태, 0.5 mg/mL 농도, -20°C 보관. 연구용 전용 제품.
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- PA5142935
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TDSGKAGADTHGR. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody has been tested in Peptide ELISA, showing an antibody detection limit dilution of 1:128,000.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving the key apoptotic proteases caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress represents the third apoptotic pathway in which caspase-12 is involved.
Caspase-12 is localized to the ER, not to the cytoplasm or mitochondrion, and is activated by ER stress, including disruption of ER calcium homeostasis, mediating ER stress-induced apoptosis.
Caspase-12 co-localizes with several ER proteins involved in Alzheimer’s disease, including γ-secretase presenilin and β-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-β.
Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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