Thermo Fisher Scientific BPI Monoclonal Antibody (4H5)

Applications

• ELISA (ELISA)
  • Tested Dilution: 1:50

Product Specifications

Product Specific Information

MA1-40128 detects BPI from human samples. The immunogen is full-length human BPI.
This antibody recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
It has been successfully used in ELISA applications. Monoclonal antibody 4H5 can be used both as coating and as detector.

Target Information

The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI is a bactericidal compound present in polymorphonuclear cells and in lower levels in eosinophils.
It binds the lipid A region of lipopolysaccharides (LPS) in gram-negative bacteria, leading to:

• Cytotoxicity via damage to bacterial membranes
• Neutralization of LPS
• Opsonization enhancing phagocytosis by neutrophils

BPI may play a key role in LPS-triggered airway disease due to its expression in airway epithelial cells.
A recombinant fragment, rBPI21 (21 kDa), confers survival advantage against pneumococcal disease by binding pneumolysin from gram-positive bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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