
Thermo Fisher Scientific BPI Monoclonal Antibody (4H5)
Human BPI 단백질을 인식하는 Mouse IgG1 단일클론 항체로, ELISA에 최적화되어 있으며 자유형 BPI만 선택적으로 결합합니다. Protein G 정제, PBS/BSA 완충액, 4°C 보관. 연구용으로만 사용됩니다.
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Applications
- ELISA (ELISA)
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H5 |
| Immunogen | Full length human BPI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2067083 |
Product Specific Information
MA1-40128 detects BPI from human samples. The immunogen is full-length human BPI.
This antibody recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
It has been successfully used in ELISA applications. Monoclonal antibody 4H5 can be used both as coating and as detector.
Target Information
The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI is a bactericidal compound present in polymorphonuclear cells and in lower levels in eosinophils.
It binds the lipid A region of lipopolysaccharides (LPS) in gram-negative bacteria, leading to:
- Cytotoxicity via damage to bacterial membranes
- Neutralization of LPS
- Opsonization enhancing phagocytosis by neutrophils
BPI may play a key role in LPS-triggered airway disease due to its expression in airway epithelial cells.
A recombinant fragment, rBPI21 (21 kDa), confers survival advantage against pneumococcal disease by binding pneumolysin from gram-positive bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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