Thermo Fisher Scientific SENP8 Polyclonal Antibody
Rabbit polyclonal antibody against human SENP8, validated for IHC(P) applications. Recognizes amino acids 171–212 of SENP8. High purity (>95%) and antigen affinity purified. Supplied as liquid form, 1 mg/mL concentration, for research use only.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 171–212 of Human SENP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803045 |
Product Specific Information
Purity is greater than 95% by SDS-PAGE.
Target Information
SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8) is a cysteine protease belonging to the ULP family of deubiquitinases. Members of this family contain a C-terminal catalytic domain and N-terminal regions that determine substrate specificity.
SENP8 (24 kDa) regulates the NEDD8 pathway by processing preNEDD8 to its mature form and removing NEDD8 from substrates such as Cullins and p53. It may prevent accumulation of hyper-neddylated Cullin and maintain mono-neddylated Cullin levels, enhancing ubiquitination efficiency by SCF ubiquitin ligases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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