Thermo Fisher Scientific Phospho-FGFR1/FGFR2 (Tyr463, Tyr466) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of tyrosine 463/466(S-E-Y(p)-E-L) derived from Human FGFR1/2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FGFR1/FGFR2,uniProtId:P11362-1,ncbiNodeId:9606,antigenRange:461-465|463-466,antigenLength:822,antigenImageFileName:PA5-37816_FGFR1FGFR2_P11362-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37816_FGFR1FGFR2_P11362-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:FGFR1/FGFR2,uniProtId:P21802-1,ncbiNodeId:9606,antigenRange:463-466|464-468,antigenLength:821,antigenImageFileName:PA5-37816_FGFR1FGFR2_P21802-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37816_FGFR1FGFR2_P21802-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2554424

Product Specific Information

A suggested positive control for Western blot is HepG2 cells.

Target Information

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.