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Thermo Fisher Scientific TOPORS Polyclonal Antibody
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TOPORS 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. E3 유비퀴틴 및 SUMO1 리가아제 기능 연구에 활용되며, 세포 성장과 p53 안정성 조절 연구에 유용합니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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마지막 업데이트 2025. 08. 04. 오전 04:58
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Thermo Fisher Scientific A302179AM TOPORS Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
477,300원VAT 포함 525,030원
Thermo Fisher Scientific A302179AT TOPORS Polyclonal Antibody 10 ul pk판매 단위 pk ·
재고 확인 필요
194,600원VAT 포함 214,060원
Thermo Fisher Scientific · Thermo Fisher Scientific TOPORS Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 995 and 1045 of Human topoisomerase I binding, arginine/serine-rich |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
TOPORS functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. It acts as a probable tumor suppressor involved in cell growth, proliferation, and apoptosis by regulating p53/TP53 stability through ubiquitin-dependent degradation. It may regulate chromatin modification through sumoylation of chromatin modification-associated proteins and participate in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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