Thermo Fisher Scientific FANCD2 Polyclonal Antibody
FANCD2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 시료에 반응하며 Monkey, Gorilla에서도 예측 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Monkey and Gorilla.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability and promotes accurate pairing of homologs during meiosis. It participates in DNA double-strand break repair via homologous recombination and single-strand annealing. FANCD2 is essential for targeting/stabilization of BLM to abnormal structures induced by replicative stress and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene cause Fanconi anemia complementation group D2, a disorder affecting bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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