Thermo Fisher Scientific Cyclophilin A Monoclonal Antibody (C1)
Cyclophilin A 단백질을 인식하는 Mouse monoclonal antibody(C1 클론). Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Pig, Rat 반응성. Protein A/G 정제, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Recombinant Mouse CYPA protein, Val2–Leu164 (Accession #P17742) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094362 |
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents — cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase implicated in T-cell activation, providing a mechanism of immunosuppression by CsA and FK506.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase), accelerating protein folding by catalyzing slow steps in proline-containing protein rearrangement. Within the cyclophilin family, CyPA (also termed CyP-18) is the most abundant and ubiquitous member, found in all vertebrate tissues and present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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