Thermo Fisher Scientific SATB1 Polyclonal Antibody
SATB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, Flow Cytometry에 적합. 인간 및 마우스 시료 반응성, 고순도 액상 형태, 4°C 또는 -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SATB1 Polyclonal Antibody
Thermo Fisher Scientific SATB1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal human SATB1 (aa 1–763) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913219 |
Product Specific Information
- Positive Control: Mouse thymus tissue lysate, SH-SY-5Y, Jurkat
- Subcellular Location: Nucleus
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in X inactivation mediated by Xist RNA during embryogenesis and lymphoma development. It binds to AT-rich DNA sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate backbone of double-stranded DNA.
SATB1 acts as a transcriptional repressor regulating nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner. It plays a key role in chromatin-loop remodeling and T-cell maturation (CD8SP).
SATB1-binding sites are preferentially targeted by HIV-1 integration machinery, and HIV-1 Tat may counteract SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.