Thermo Fisher Scientific PFKL Polyclonal Antibody
Thermo Fisher Scientific의 PFKL Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 PFKL 단백질을 검출하기 위한 고품질 항체입니다. Western blot, IHC, ICC/IF에 적합하며, 합성 펩타이드 면역원으로 제작되었습니다. 액상 형태로 -20°C에 보관하며 연구용으로 사용됩니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PFKL (Accession P17858), corresponding to amino acid residues P704–Y754 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850532 |
Product Specific Information
Antibody detects endogenous levels of total K6PL.
Target Information
Phosphofructokinase (PFK) is a major regulatory enzyme that catalyzes sugar metabolism, essential for energy production and normal cell function. In humans, three structural loci control PFK subunits—M (muscle), L (liver), and P (platelet)—which are variably expressed across tissues. Human fibroblasts and leukocytes express all three genes. PFK forms tetramers composed of combinations of these subunits, resulting in five possible isozymes (M4, M3L, M2L2, ML3, L4). It is an allosteric enzyme activated by ADP, AMP, or fructose bisphosphate, and inhibited by ATP or citrate. PFK catalyzes the key regulatory step in glycolysis. Deficiency may cause episodic illness with dark urine following strenuous exercise. Elevated red cell PFK levels are observed in individuals with Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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