Thermo Fisher Scientific NOG Monoclonal Antibody (2E10)
인간 Noggin 단백질을 표적으로 하는 마우스 모노클로날 항체. Western Blot과 ELISA에 적합하며, 고순도 친화 크로마토그래피로 정제됨. PBS(pH 7.4) 용액 형태로 제공되며 보존제 없음. 연구용으로만 사용 가능.
- 카탈로그번호
- H00009241-M09
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific NOG Monoclonal Antibody (2E10)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E10 |
| Immunogen | NOG (AAH34027, 28–232 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells.
This process is achieved through signals from:
- WNT protein (WNT3A) to stabilize beta-catenin
- Noggin, a bone morphogenetic protein inhibitor
Noggin mutations have been identified in families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1), characterized by multiple joint fusions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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