Thermo Fisher Scientific POLA1 Polyclonal Antibody
Thermo Fisher Scientific의 POLA1 폴리클로날 항체로 인간 POLA1 단백질을 타겟으로 합니다. IHC(P) 및 ICC/IF 실험에 적합하며, 항원 친화 크로마토그래피로 정제된 고순도 항체입니다. PBS 기반 저장용액과 글리세롤 포함, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific POLA1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLA1. Recombinant protein control fragment (Product #RP-92178). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645742 |
Product Specific Information
Immunogen sequence:
VDLEPMAAKA WDKESEPAEE VKQEADSGKG TVSYLGSFLP DVSCWDIDQE GDSSFSVQEV QVDSSHLPLV KGADEEQVFH FYWLDAYEDQ YNQPGVVFLF GKVWIESAET HVSCCVMVK
Highest antigen sequence identity to the following orthologs:
- Mouse: 75%
- Rat: 76%
Target Information
DNA replication, recombination, and repair processes essential for genomic stability require exonucleases. These enzymes process Okazaki fragments during replication and excise damaged DNA during repair. The DNA polymerase family (alpha, beta, delta, epsilon) is involved in these mechanisms.
- DNA pol delta and epsilon are multisubunit enzymes.
- DNA pol gamma replicates mitochondrial DNA.
- DNA pol zeta mediates damage-induced mutagenesis.
- DNA pol theta functions as a DNA polymerase-helicase in interstrand crosslink repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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