Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
Thermo Fisher Scientific의 LAMTOR1 폴리클로날 항체로, 인간 LAMTOR1 단백질을 인식합니다. IHC(P)에서 1:200–1:500 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼(40% 글리세롤 포함)로 공급되며, 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LAMTOR1. Recombinant protein control fragment (Product #RP-95926) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643265 |
Product Specific Information
Immunogen sequence:
NEDSDQDREE RKLLLDPSSP PTKALNGAEP NYHSLPSART DEQALLSSIL AKTASNIIDV SAADSQGMEQ HEYMDRARQY STRLAVLSSS LTHWKKLPPL PSLTSQPHQV LASEPIPFSD LQQVSRIAAY AYSALSQIRV DAKEELVV
Highest antigen sequence identity to orthologs:
- Mouse: 99%
- Rat: 97%
Target Information
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which target mTORC1 to lysosomal surfaces. This normal endosomal trafficking is utilized by certain viruses, including coronavirus, which shows increased replication when C11orf59 is interfered with.
C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis.
C11orf59 and PPAR-alpha cooperate to regulate lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion and dysregulation of the normal mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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