Thermo Fisher Scientific SLC22A17 Monoclonal Antibody (OTI2D6), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins mainly expressed in kidney and liver.
They contain 12 predicted alpha-helical transmembrane domains and a large extracellular loop between TMDs 1 and 2.
Members of the SLC22 family function as:

• Uniporters mediating facilitated diffusion (OCTs)
• Anion exchangers (OAT1, OAT3, URAT1)
• Na(+)/L-carnitine cotransporters (OCTN2)

These transporters are involved in the absorption and excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, playing homeostatic roles in brain and heart.
Mutations in SLC22 family genes may lead to diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia, and can affect drug absorption or excretion.
Recent studies show SLC22A17 (receptor for Lipocalin 2) is highly expressed in hematopoietic stem cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.