Thermo Fisher Scientific ATG4B Monoclonal Antibody (OTI1A3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cysteine protease ATG4B is an enzyme encoded by the ATG4B gene. Autophagy is a critical cellular process that regulates the turnover of damaged organelles and proteins. ATG4B functions as a deubiquitin-like protease, playing dual roles in the core autophagy machinery. It cleaves the C-terminal amino acid of ATG8 family proteins (MAP1LC3, GABARAPL1, GABARAPL2, GABARAP) to expose a C-terminal glycine, which is essential for conjugation to phosphatidylethanolamine (PE) and membrane insertion during autophagy. ATG4B is mainly expressed in skeletal muscle, brain, heart, liver, and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.