Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Predicted to react with Chimpanzee based on 100% sequence identity

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein that phosphorylates multiple downstream targets involved in cell-cycle regulation, including P53, Mdm2, BRCA1, and SMC1. ATM is essential for repairing double-stranded DNA breaks induced by ionizing radiation and other mutagens.
ATM’s C-terminal region shows extensive homology to catalytic domains of PI3 kinases. It becomes autophosphorylated and upregulated upon exposure to ionizing radiation. AT cells are hypersensitive to radiation, show impaired DNA synthesis inhibition, and delayed p53 induction.
DNA damage activates ATM-kinase, triggering kinase cascades that regulate cell cycle, apoptosis, and DNA repair. ATM also interacts with Nbs1 and Chk2 in the E2F1 apoptotic pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.