Thermo Fisher Scientific TRRAP Polyclonal Antibody
TRRAP 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 원숭이, 랫트에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the human TRRAP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 125.4 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986310 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase (HAT) activity, contributing to epigenetic transcription activation. It is a component of the NuA4 HAT complex responsible for acetylation of nucleosomal histones H4 and H2A.
TRRAP plays a key role in MYC transcription activation and cell transformation by MYC. It is required for p53/TP53-, E2F1-, and E2F4-mediated transcription activation and also participates in adenovirus E1A-mediated transcription activation.
TRRAP likely links transcription factors such as E1A, MYC, or E2F1 to HAT complexes like STAGA, enabling transcription activation. It may also be involved in mitotic checkpoint regulation and normal cell cycle progression, and is part of a SWR1-like complex that removes histone H2A.Z/H2AFZ from nucleosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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