Thermo Fisher Scientific Phospho-SHP2 (Tyr580) Polyclonal Antibody
Phospho-SHP2 (Tyr580) 특이적 폴리클로날 항체로 Western blot 및 Immunoprecipitation에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 비결합 항체. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr580 of human SHP-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 22 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982321 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, known as signaling molecules that regulate diverse cellular processes such as cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains that function as phospho-tyrosine binding domains and mediate substrate interactions. It is widely expressed in most tissues and plays a regulatory role in various signaling events important for mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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