Thermo Fisher Scientific SHANK1/SHANK3 Monoclonal Antibody (N367/51), FITC
SHANK1/SHANK3 단백질을 인식하는 FITC 결합 단일클론 항체로, WB·IHC·ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 단백질 G 정제 및 보존제 무첨가. 4°C 암조건 보관.
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Thermo Fisher Scientific SHANK1/SHANK3 Monoclonal Antibody (N367/51), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N367/51 |
| Immunogen | Fusion protein amino acids 538–626 (SH3 domain) of rat SHANK3 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932128 |
Additional Formats
- APC (MA5-45673)
- PE (MA5-45676)
- PerCP (MA5-45675)
- Request custom conjugation
Product Specific Information
- Mouse: 100% identity (89/89 amino acids identical)
- Human: 97% identity (87/89 amino acids identical)
- ~70% identity with SHANK1 and SHANK2
- 1 µg/mL of MA5-45674 detects SHANK1/SHANK3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as secondary antibody
- Detects approximately 190 kDa
- Cross-reacts with SHANK1, does not cross-react with SHANK2
- Formerly sold as clone S367-51
Target Information
SHANK proteins are major scaffold components of the postsynaptic density, interacting with multiple proteins to orchestrate dendritic spine and synapse formation, maturation, and maintenance. They interconnect NMDA-type and metabotropic glutamate receptors through complexes with GKAP/PSD-95 and HOMER, linking to the actin cytoskeleton. SHANK3 regulates actin dynamics, neuronal growth cone motility, and receptor-mediated synaptic transmission and plasticity. It may be required at early synapse formation stages and modulated by IGF1 for maturation.
References: PubMed:21606927, 21795692, 23100419, 23897824, 24089484
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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