Thermo Fisher Scientific SN38 Recombinant Rabbit Monoclonal Antibody (PSH0-06)
SN38에 특이적인 재조합 토끼 단클론 항체로 Western blot 및 ELISA에 적합. HEK293 세포에서 발현된 IgG 형식의 항체이며, Protein A로 정제됨. SN38은 이리노테칸의 활성 대사체로, 항암 연구에 활용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PSH0-06 |
| Immunogen | SN38-OVA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090454 |
Product Specific Information
Product MA5-50768 was used in a Competitive ELISA and Indirect ELISA.
Target Information
SN38 is a chemical compound that belongs to the class of topoisomerase I inhibitors. It is the active metabolite of irinotecan, a chemotherapeutic drug used in the treatment of various cancers, particularly colorectal cancer.
SN38 exerts its anti-cancer effects by inhibiting topoisomerase I, an enzyme involved in DNA replication and repair. This inhibition prevents DNA unwinding, leads to DNA damage accumulation, and induces cancer cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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