Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI2D3), TrueMAB
Human ESR1 단백질(Estrogen Receptor alpha)을 인식하는 Mouse IgG1 단일클론 항체로, WB 및 IHC(P)에서 검증됨. Lyophilized 형태로 제공되며, PBS buffer와 trehalose 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–310 of human ESR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors.
The estrogen receptor is a ligand-activated transcription factor that, upon estrogen binding, undergoes conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA.
ER regulates gene transcription by recruiting coactivator or corepressor proteins.
There are two receptor forms, alpha (ESR1) and beta (ESR2), encoded by separate genes.
At least four isoforms of estrogen receptor-alpha are known (66 kDa, 53 kDa, 47 kDa, 35 kDa).
ERs are expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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