Thermo Fisher Scientific IKK beta Recombinant Rabbit Monoclonal Antibody (8X6V3)
IKK beta 단백질을 표적하는 재조합 토끼 단클론 항체로, NF-kappa-B 신호전달 연구에 적합. ICC/IF 및 ELISA에 사용 가능하며, 높은 특이성과 재현성을 제공. HEK293 발현 시스템에서 생산, 액상 형태로 공급.
- 카탈로그번호
- MA535319
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8X6V3 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 450–756 of human IKK beta (O14920) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849221 |
Product Specific Information
Immunogen sequence:
GQRAAMMNLL RNNSCLSKMK NSMASMSQQL KAKLDFFKTS IQIDLEKYSE QTEFGITSDK LLLAWREMEQ AVELCGRENE VKLLVERMMA LQTDIVDLQR SPMGRKQGGT LDDLEEQARE LYRRLREKPR DQRTEGDSQE MVRLLLQAIQ SFEKKVRVIY TQLSKTVVCK QKALELLPKV EEVVSLMNED EKTVVRLQEK RQKELWNLLK IACSKVRGPV SGSPDSMNAS RLSQPGQLMS QPSTASNSLP EPAKKSEELV AEAHNLCTLL ENAIQDTVRE QDQSFTALDW SWLQTEEEEH SCLEQAS
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on two critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome.
Free NF-kappa-B is then translocated into the nucleus and activates transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.
Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-35319_IKK_beta_O14920-1_Rabbit.svg, MA5-35319_IKK_beta_O14920-1_Rabbit_PDP.jpeg)
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