Thermo Fisher Scientific pro-Brain Natriuretic Peptide Monoclonal Antibody (11D1)
인간 proBNP를 검출하는 Thermo Fisher Scientific의 단클론 항체로, 웨스턴 블롯 등에 사용 가능. Mouse IgG1 형식이며, Protein A로 정제된 액상 형태. 심부전 관련 바이오마커 연구용으로 적합.
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11D1 |
| Immunogen | Synthetic peptide corresponding to residues L(28) S E L Q V E Q T S L E P L Q E S P(45) of human proBNP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560692 |
Product Specific Information
MA1-20584 detects proBNP in human samples.
Target Information
In cardiac tissue, brain natriuretic peptide (BNP) is synthesized as a 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa signal peptide and a 108 aa pro-BNP.
Proteolytic digestion of pro-BNP results in formation of a 76 aa amino-terminal NT-proBNP and a biologically active 32 aa BNP hormone molecule.
Both proBNP and NT-proBNP circulate in human plasma and serve as markers for early diagnosis of left ventricular dysfunction and as prognostic indicators for cardiac complications in patients with heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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