Thermo Fisher Scientific Human/Mouse/Rat Activin A Recombinant Protein, PeproTech
Human/Mouse/Rat Activin A 재조합 단백질로 TGF-β 신호 연구에 활용 가능. CHO 세포에서 발현된 26 kDa 단백질이며 ≥95% 순도 보장. 세포 증식 억제 활성 검증 완료. 연구용으로만 사용 가능.
- 카탈로그번호
- 120-14P-xxxxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human/Mouse/Rat Activin A Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (26 available)
Miscellaneous PubMed (Misc)
- Refer to publications (4 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Expression System | CHO cells |
| Amino Acid Sequence | GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS |
| Molecular Weight | 26 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | < 1 EU/µg |
| Activity | Inhibits proliferation of mouse MPC-11 cells. Expected ED50 ≤ 2.0 ng/ml (≥ 5 × 10⁵ units/mg). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- Catalog No. 120-14P-1MG is supplied as 2 × 500 µg (120-14P-500UG).
- Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two betaA chains, each with 116 amino acid residues.
- Shipped at ambient temperature.
- Refer to the lot-specific Certificate of Analysis for storage, handling, and reconstitution details.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-β) superfamily. They signal through a heteromeric complex of receptor serine kinases, including at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins with extracellular cysteine-rich domains and cytoplasmic serine/threonine kinase domains.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression. Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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