Thermo Fisher Scientific CRY2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
EIQENHDETY GVPSLEELGF PTEGLGPAVW QGGETEALAR LDKHLERKAW VANYERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYYRLW DLYKKVKRNS T

Target Information

Various biochemical, physiological, and behavioral processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/post-translation-based feedback loop.

Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear homology to blue-light receptors and photolyases. In Drosophila, CRY acts as a photoreceptor for the circadian clock by binding to the clock component TIM in a light-dependent manner to block its function.

Mammalian CRY1 and CRY2 interact with circadian genes CLOCK and BMAL1, as well as PER1, PER2, and TIM, functioning as light-independent components of the circadian clock. They regulate Per1 transcriptional cycling via interactions with both activators and feedback inhibitors.

Mutant mice lacking Cry1 or Cry2 display altered periodicity of locomotor activity, indicating the essential balance between Cry1 and Cry2 for proper circadian function. Double-mutant mice exhibit arrhythmicity, confirming the absence of an internal circadian clock.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.