Thermo Fisher Scientific beta 1-Adrenergic Receptor (extracellular) Polyclonal Antibody, Atto 488

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:60

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• The antibody ships as a lyophilized powder at room temperature.
• Upon arrival, store at −20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at −20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular data reveal significant heterogeneity within this receptor family.
Nine receptor subtypes have been identified:

• Alpha-1 AR: 1A/D, 1B, 1C
• Alpha-2 AR: 2A, 2B, 2C
• Beta AR: 1, 2, 3

ARs are involved in disease states such as hypertension, cardiac dysfunction (heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
Beta-1 adrenergic receptors (B1ARs) contribute to cardiac function, development, and metabolism.
Knockout studies show that most mice lacking the B1AR gene die prenatally, and survivors exhibit abnormal cardiac function.
Cardiac B1AR density is regulated by thyroid hormones at the transcriptional level and modulated by the catecholamine-sensitive adenylyl cyclase system.
Evidence also indicates that cAMP affects B1AR regulation through CREM family transcription factors in transformed cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.