Thermo Fisher Scientific MUC1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:300–1:10,000
• Publications: View 1 publication

Product Specifications

Product Specific Information

• This product is preservative-free.
• It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
• This antibody has specificity for Mouse MUC1.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic; each allele encodes a product with a different number of repeats (30–90), leading to large differences in molecular weight.
It is expressed abundantly in >90% of breast carcinomas and metastases.
Transgenic MUC1 associates with all four cebB receptors and localizes with erbB1 (EGFR) in lactating glands.
The MUC1 gene contains seven exons and produces several alternatively spliced variants.
Overexpression, aberrant intracellular localization, and changes in glycosylation of MUC1 are associated with carcinomas.
Multiple alternatively spliced transcript variants encoding different isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.