Thermo Fisher Scientific SIRP alpha Polyclonal Antibody
SIRP alpha 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간 SIRPa1 아미노산 487–503 서열 기반 면역원 사용. 비결합형 액상 형태로 4°C 단기 보관, -20°C 장기 보관 권장. 세포 신호 조절 및 면역 반응 연구용.
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Thermo Fisher Scientific SIRP alpha Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to amino acids 487–503 of human SIRPa1. The sequence differs from mouse, rat, and bovine by one amino acid. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2187943 |
Product Specific Information
- Positive control: THP-1 whole cell lysate suggested.
- Immunogen corresponds to amino acids 487–503 of human SIRPa1, differing by one amino acid from mouse, rat, and bovine.
- Store as a concentrated solution and centrifuge briefly before opening the vial.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on myeloid-origin cells such as granulocytes, dendritic cells, macrophages, mast cells, and hematopoietic stem cells.
It acts as a substrate for activated tyrosine kinases (EGFR, PDGFR, src, insulin receptor) and negatively regulates receptor tyrosine kinase-coupled signaling pathways.
Binding to CD47 triggers phosphorylation of ITIMs in the cytoplasmic region, recruiting tyrosine phosphatases SHP-1 and SHP-2.
This interaction regulates processes such as inhibition of macrophage phagocytosis and activation of T cells and DCs.
SIRP alpha influences cellular responses to serum, growth factors, insulin, oncogenes, growth hormones, and cell adhesion, playing roles in various physiological and pathological processes.
Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated tumor cell destruction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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