Thermo Fisher Scientific MTSS1 Polyclonal Antibody
MTSS1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 적합합니다. 세포 성장과 발달 조절 연구에 유용하며, actin cytoskeleton 재구성 관련 연구에 활용됩니다. 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (176 LEETEKQAVRKALIEERGRFC 196) of MTSS1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2540726 |
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"] was first discovered as missing transcripts from metastatic bladder and prostate cancer cells.
MTSS1 is a 755 amino acid protein with multidomain and scaffolding functions. It contains:
- A proline-rich/SH3 binding region
- A serine-rich region with EGF or PDGF/Src consensus sites
- An actin-binding WH2 motif at the C-terminus
- An N-terminal IMD domain (IRSp53-MIM domain) that interacts with membranes and bundles actin filaments
The WH2 domain binds actin monomers and plays a key role in actin cytoskeleton reorganization. MTSS1 interacts with cortactin via SH3 domains and enhances cortactin- and Arp2/3-dependent actin polymerization.
It is involved in cell motility and morphogenesis and interacts with sonic hedgehog/Gli signaling in epidermal cells.
MTSS1 acts as an important regulator of cell growth and development and is expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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