Thermo Fisher Scientific FMNL2 Polyclonal Antibody
FMNL2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 등 다양한 종에 반응하며, Protein G로 정제된 고순도 항체입니다. PBS buffer에 0.05% sodium azide를 포함하고 있으며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acid 1–50 of human Formin-like protein 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540720 |
Target Information
Formin-like protein 2 (FMNL2) is a cytoplasmic phosphoprotein belonging to the formin homology domain-containing protein family. It contains a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Although its exact function remains unclear, FMNL2 is suggested to play a role in the Wnt signaling pathway.
Formin-related proteins are important in morphogenesis, cytokinesis, and cell polarity. Several alternatively spliced transcript variants have been reported, though their full-length structures are not fully determined. FMNL2 has been associated with diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. It may contribute to polarity control, invasion, migration, or metastasis through actin filament nucleation and may be regulated by Rho family GTPases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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