Thermo Fisher Scientific Phospho-Syk (Tyr525, Tyr526) Polyclonal Antibody
Phospho-Syk (Tyr525, Tyr526) 특이적 폴리클로날 항체로, Human, Mouse, Rat 반응성. WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A 정제 및 고순도 액상 형태. 연구용으로만 사용 가능.
- 카탈로그번호
- BS-3434R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-Syk (Tyr525, Tyr526) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyr525/526 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases considered potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates downstream adaptor proteins. This provides docking sites for subsequent signaling pathways, including calcium mobilization, cytoskeleton remodeling, and transcriptional activation of specific genes. Syk binds receptor assemblies through its SH2 domains interacting with phosphorylated ITAM motifs of the receptor, which are phosphorylated by Src-family kinases that also activate Syk via phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.