Thermo Fisher Scientific BABAM1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human BABAM1 (HSPC142) for Western blot applications. Recognizes C-terminal region of HSPC142. Predicted cross-reactivity with mouse, rat, monkey, and bovine. Supplied as liquid, 1 mg/mL, stored at 4°C short-term or...
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human HSPC142 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792643 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (95%), Rat (91%), Rhesus Monkey (98%), Bovine (95%).
- Positive Control: human C19orf62-transfected 293T cells.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
HSPC142 is a component of the BRCA1-A complex, which specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, directing the BRCA1-BARD1 heterodimer to double-strand breaks (DSBs). The BRCA1-A complex also exhibits deubiquitinase activity that removes Lys-63-linked ubiquitin from histones H2A and H2AX. Within this complex, HSPC142 is essential for complex integrity and localization at DSBs. It is also a component of the BRISC complex, which cleaves Lys-63-linked ubiquitin and helps maintain the stability and activity of associated deubiquitinases.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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