Thermo Fisher Scientific CD127 Monoclonal Antibody (40131)
Human CD127(IL-7Rα) 인식용 Mouse IgG1 단클론 항체로 Western blot 및 Flow cytometry에 적합. Lyophilized 형태로 제공되며 PBS + 5% trehalose buffer 구성. Protein A/G 정제, 무보존제, -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 40131 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-7 R alpha extracellular domain |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609352 |
Product Specific Information
- In Western blots, approximately 5% cross-reactivity was observed with recombinant human IL-10 R, IL-2 R beta, IL-5 R alpha, and IL-6 R.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CD127 (Interleukin-7 receptor alpha, IL-7Rα) is a glycoprotein involved in the regulation of lymphopoiesis. The receptor functions as an alpha/gamma chain heterodimer, where the gamma(c) chain also associates with the interleukin-2 receptor to activate signal transduction. The alpha chain determines specific signaling events through its association with cytoplasmic molecules.
CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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