Thermo Fisher Scientific TCTN2 Polyclonal Antibody
TCTN2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. Affinity chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TCTN2 (Accession Q96GX1), corresponding to amino acid residues M414–S464 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854112 |
Product Specific Information
This antibody detects endogenous levels of total TCTN2.
Target Information
TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not fully characterized, it shares 49% similarity with TCTN1. TCTN1 is expressed during embryonic development in regions involved in Hh signaling, beginning at the gastrulation stage in the ventral node. Mutant TCTN1-expressing mice die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating TCTN1 acts as an Hh activator. At later developmental stages, TCTN1 may also act as a repressor in the anterior and posterior neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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