Thermo Fisher Scientific GPR182 Polyclonal Antibody
GPR182 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며 인간 시료에 반응. 합성 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GPR182 (Accession O15218), corresponding to amino acid residues N321–A371. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899956 |
Product Specific Information
Antibody detects endogenous levels of total GPR182.
Target Information
Adrenomedullin (ADM) is a hypotensive peptide belonging to a peptide superfamily that includes the calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed. It is also produced by most contractile cells and is upregulated during sepsis and ischemia.
Three distinct receptors can bind ADM: ADM receptor (also designated L1), RDC-1, and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine CRLR binding specificity. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or RAMP3 results in ADM binding.
The ADM receptor, a seven-transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in the heart, brain, skeletal muscle, immune system, adrenal gland, and liver. It mediates ADM signaling through G proteins that activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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