Thermo Fisher Scientific Androgen Receptor V7 (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR.V7/9125R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Breast, LNCap cells, human testis, prostate, or prostate carcinoma
• Cellular Location: Nucleus

Target Information

The androgen receptor (AR) gene spans more than 90 kb and encodes a protein with three major functional domains: N-terminal domain, DNA-binding domain, and androgen-binding domain. The receptor acts as a steroid hormone–activated transcription factor. Upon ligand binding, it dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

The gene contains two polymorphic trinucleotide repeat regions encoding polyglutamine and polyglycine tracts in the N-terminal domain. Expansion of the polyglutamine tract (from 9–34 to 38–62 repeats) causes spinal bulbar muscular atrophy (SBMA, Kennedy’s disease). Mutations can also cause complete androgen insensitivity (CAIS). Alternative splicing generates multiple transcript variants encoding different isoforms.
[provided by RefSeq, Jan 2017]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.