Thermo Fisher Scientific SATB2 Monoclonal Antibody (CL0323)
SATB2 단백질을 인식하는 Mouse monoclonal antibody(CL0323)로, Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료에 반응하며, Protein A로 정제된 액상형 항체. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0323 |
| Immunogen | Recombinant protein corresponding to Human SATB2 (amino acids 193–307) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848882 |
Product Specific Information
Immunogen sequence:
KECPLSQSMI SSIVNSTYYA NVSATKCQEF GRWYKKYKKI KVERVERENL SDYCVLGQRP MHLPNMNQLA SLGKTNEQSP HSQIHHSTPI RNQVPALQPI MSPGLLSPQL SPQLV
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate backbone of double-stranded DNA. It functions as a transcription factor that regulates nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling. SATB2 also serves as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron (UL1) specific genetic programs and repressing deep-layer neuron (DL) and UL2 genes, likely through modulation of BCL11B expression. It acts as a repressor of Ctip2 and plays a regulatory role in corticocortical connection development in the cerebral cortex. Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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