Thermo Fisher Scientific Phospho-Paxillin (Ser178) Recombinant Rabbit Monoclonal Antibody (21H7L6)
Phospho-Paxillin (Ser178) 인산화 단백질 검출용 recombinant rabbit monoclonal 항체. Western blot 및 ICC/IF에 적합하며, 높은 특이성과 재현성을 제공. Human에 반응하며 Monkey, Cat, Mouse에서도 예측 반응. 단백질 A 정제, PBS buffer 보관.
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- 702386
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21H7L6 |
| Immunogen | Peptide corresponding to Human PXN (aa 173–181) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633014 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, and Mouse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is influenced by changes in cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, independently of the extracellular matrix. Although initially discovered in fibroblasts, paxillin phosphorylation may also play a role during neurite extension in differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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