Thermo Fisher Scientific Phospho-Syk (Tyr323, Tyr317) Recombinant Rabbit Monoclonal Antibody (6H48L23)
인간 Syk 단백질의 Tyr323 및 Tyr317 인산화를 인식하는 재조합 토끼 단클론 항체입니다. Western blot 및 면역세포염색에 적합하며, 높은 특이성과 일관된 로트 간 재현성을 제공합니다. 단백질 A 정제, PBS 완충액, 0.09% sodium azide 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6H48L23 |
| Immunogen | Peptide corresponding to Human Syk (aa 319–327) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2632968 |
Product Specific Information
This antibody is predicted to react with Monkey, Horse, Cat, Mouse, and Rat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
Spleen tyrosine kinase (SYK) is a cytoplasmic tyrosine kinase, along with ZAP70, considered a potential drug target for allergic and autoimmune disorders, and may also play a role in cancer.
Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates downstream adaptor proteins, providing docking sites for signaling cascades such as calcium mobilization, cytoskeleton remodeling, and gene transcription.
Syk interacts with receptor assemblies via its SH2 domains binding to phosphorylated ITAM motifs, which are modified by Src-family kinases that also activate Syk through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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