Thermo Fisher Scientific SCNN1G Polyclonal Antibody
SCNN1G 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인체, 마우스, 랫트 반응성이 있으며, 액상 형태로 제공됩니다. ENaC 감마 단백질 검출에 사용되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SCNN1G (Accession P51170), corresponding to amino acid residues H610–L649 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852500 |
Product Specific Information
This antibody detects endogenous levels of total ENaC gamma.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this family share structural features including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays a critical role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron, thereby regulating blood pressure. ENaC activity is thought to be modulated by association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can lead to severe hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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