Thermo Fisher Scientific SCNN1G Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total ENaC gamma.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this family share structural features including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of ENaC: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays a critical role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron, thereby regulating blood pressure. ENaC activity is thought to be modulated by association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can lead to severe hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.