Thermo Fisher Scientific NALP12 Polyclonal Antibody
Thermo Fisher Scientific의 NALP12 Polyclonal Antibody는 인간 및 랫트 시료에서 NALP12 단백질 검출에 적합한 고품질 항체입니다. Western blot과 ELISA에 최적화되어 있으며, 고순도 친화성 크로마토그래피로 정제되었습니다. 세포 내 염증 반응 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: View 1 publication
ELISA
- Tested Dilution: 1 µg/mL
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 862–1061 of human NLRP12 (NP_6532881) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.07 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805820 |
Product Specific Information
- Positive Samples: Rat spleen
- Cellular Location: Cytoplasm
- Immunogen Sequence:
WLKICRLTAA ACDELASTLS VNQSLRELDL SLNELGDLGV LLLCEGLRHP TCKLQTLRLG ICRLGSAACE GLSVVLQANH NLRELDLSFN DLGDWGLWLL AEGLQHPACR LQKLWLDSCG LTAKACENLY FTLGINQTLT DLYLTNNALG DTGVRLLCKR LSHPGCKLRV LWLFGMDLNK MTHSRLAALR VTKPYLDIGC
Target Information
NALP proteins are cytoplasmic proteins forming a subfamily within the larger CATERPILLER family, playing crucial roles in cell proliferation and reproduction.
NALP12 (Monarch-1) possesses:
- C-terminal leucine-rich repeat (LRR) region
- N-terminal Pyrin domain (PYD)
- NACHT domain and NACHT-associated domain
NALP12 acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation through TLR-signaling molecules (MyD88, IRAK-1, TRAF6, RIPK1) in activated monocytes.
Mutations in NALP12 are associated with hereditary periodic fever syndromes.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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