Thermo Fisher Scientific NALP12 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 1 publication 1 publication

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_6532881) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NALP12,uniProtId:P59046-1,ncbiNodeId:9606,antigenRange:862-1061,antigenLength:1061,antigenImageFileName:PA5-89879_NALP12_P59046-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89879_NALP12_P59046-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.07 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805820

Product Specific Information

Positive Samples: Rat spleen; Cellular Location: Cytoplasm

Immunogen sequence: WLKICRLTAA ACDELASTLS VNQSLRELDL SLNELGDLGV LLLCEGLRHP TCKLQTLRLG ICRLGSAACE GLSVVLQANH NLRELDLSFN DLGDWGLWLL AEGLQHPACR LQKLWLDSCG LTAKACENLY FTLGINQTLT DLYLTNNALG DTGVRLLCKR LSHPGCKLRV LWLFGMDLNK MTHSRLAALR VTKPYLDIGC

Target Information

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.