Thermo Fisher Scientific ZAK Polyclonal Antibody
ZAK 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 적합합니다. Mouse 및 Rat 시료에서 반응하며, 세포질과 핵에 위치한 ZAK 단백질 검출에 사용됩니다. 액상 형태로 제공되며, -20°C 보관이 필요합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–312 of human ZAK (NP_5984071) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805817 |
Product Specific Information
Immunogen sequence:
EEMDMDHIMT WATDVAKGMH YLHMEAPVKV IHRDLKSRNV VIAADGVLKI CDFGASRFHN HTTHMSLVGT FPWMAPEVIQ SLPVSETCDT YSYGVVLWEM LTREVPFKGL EGLQVAWLVV EKNERLTIPS SCPRSFAELL HQCWEADAKK RPSFKQIISI LESMSNDTSL PDKCNSFLHN KAEWRCEIEA TLERLKKLER DLSFKEQELK ERE
Positive Samples: Mouse heart, Mouse brain, Mouse skeletal muscle, Rat heart, Rat skeletal muscle
Cellular Location: Cytoplasm, Nucleus
Target Information
ZAK is a leucine zipper-containing mitogen-activated protein kinase related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK belongs to the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. It mediates gamma radiation signaling leading to cell cycle arrest, playing a role in checkpoint regulation and exhibiting pro-apoptotic activity. Alternate splice variants encoding different isoforms have been characterized.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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