Thermo Fisher Scientific AR Monoclonal Antibody (UMAB240), UltraMAB
안드로겐 수용체(AR)를 표적하는 UMAB240 단클론 항체로, 사람 시료에 반응하며 IHC(P) 분석에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적 보관이 가능합니다. 연구용으로만 사용됩니다.
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- 2개 옵션
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB240 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 420–659 of human AR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes. AR signaling is crucial for development and function of male reproductive organs (prostate, epididymis) and also affects nonreproductive tissues such as muscle, hair follicles, and brain. Dysregulation of AR signaling is associated with diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in AR can cause complete androgen insensitivity syndrome (CAIS).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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