Thermo Fisher Scientific CLACP/COL25A1 Polyclonal Antibody
CLACP/COL25A1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, Protein A로 정제된 고품질 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CLACP/COL25A1 (amino acids 581–654) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (Aβ). Although production and deposition of Aβ appear closely related to the pathogenesis of AD, current evidence suggests that Aβ alone is not sufficient to cause neuronal death and symptoms of dementia.
A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component) and its precursor CLAC-P, are deposited with extracellular beta-amyloid and have been implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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