Thermo Fisher Scientific SERPINA3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunoprecipitation (IP)

25 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin A3/alpha 1-Antichymotrypsin Asn26-Ala423 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SERPINA3,uniProtId:P01011-1,ncbiNodeId:9606,antigenRange:26-423,antigenLength:423,antigenImageFileName:PA5-46907_SERPINA3_P01011-1_Goat.svg,antigenImageFileNamePDP:PA5-46907_SERPINA3_P01011-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609829

Product Specific Information

In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) Serpin A1 is observed, and less than 3% cross-reactivity with recombinant human (rh) Serpin A1, rhSerpin A3N, rhSerpin A4, rhSerpin A5, rhSerpin A9, rhSerpin C1, rhSerpin F2, and rhSerpin F1/PEDF is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

SERPINA encodes Alpha 1-ACT. It is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer`s disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.